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71.
Mota R Bruch-Gerharz D Kruse R Hengge UR 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》2007,58(4):292-293
Ohne Zusammenfassung 相似文献
72.
73.
Kourí V González EE Martínez PA Capó V González R Pérez L Viera J Cardellá L Hengge UR 《Scandinavian journal of infectious diseases》2007,39(11-12):1038-1044
To investigate the association between human CMV glycoprotein B (gB) genotypes and CMV disease, we retrospectively analysed 73 biological samples from 56 Cuban patients with different CMV-related diseases using a multiplex nested PCR for detection of the reported 5 CMV gB genotypes. All 4 main genotypes 1 to 4 were found in the clinical samples while no genotype 5 was detected. Among the individuals analysed, genotype gB-2 was the most prevalent (38%) followed by gB-1 (30%) and mixed infections (16%) being mainly detected among immunosuppressed patients (7 out of 9), although there was no association between mixed infections and CMV rejection in transplant recipients. Genotype gB-4 was the least frequent (5 patients), which was almost exclusively detected in mixed infections (4 out of 5, p<0.0001). Genotype gB-1 was more frequently detected in AIDS patients (47%) although it was not statistically significant, while 68% of transplant patients showed mixed infections (p<0.05). This study represents the first report of human CMV gB genotypes in Cuban patients; however, the study is limited by the small number patients, thus making it difficult to draw firm conclusions about the distribution of CMV genotypes in Cuba. Nevertheless, this preliminary report has allowed us to identify that the main 4 CMV genotypes are present in the Cuban population, with genotypes 2 and 1 being the most frequent strains. 相似文献
74.
Hengge UR 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》2008,59(8):633-641
Tourists in the tropics often develop reactions to bites or stings of mosquitoes, fleas, mites, ants, bedbugs, beetles, larva, millipedes, spiders and scorpions. In addition, they may have fresh or salt water exposure to sponges, corals, jellyfish and sea urchins with resultant injury and inflammation. Bacterial skin infections (pyodermias) can follow bites or stings as well as mechanical trauma. The most common bacteria involved in skin infections are staphylococci and streptococci. For tourists, bacterial infections are often complicating a pruritic bite reaction and scratching. It is important to know the cause of the bite reaction and pyoderma in order to take appropriate therapeutic measures. 相似文献
75.
Hengge UR 《The Journal of investigative dermatology》2008,128(3):499-500
In this issue, Wally et al. (2008) report successful gene expression repair by spliceosome-mediated RNA trans-splicing (SMaRT), a novel achievement in molecular medicine. In their model, SMaRT was able to replace a mutation of the plectin gene in epidermolysis bullosa simplex with muscular dystrophy. This approach is particularly attractive for skin gene therapy of dominant-negative mutations present in a number of blistering genodermatoses. 相似文献
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77.
A human leukemia cell line, PER-255, was established from the bone marrow of a 5-year-old boy with features typical of lymphomatous T- acute lymphoblastic leukemia (T-ALL). The leukemic origin of cell line PER-255 is indicated by its cytochemical and immunologic similarity to the patient's fresh leukemic cells, which correspond to immature cortical thymocytes. Southern blot analysis showed that the IgJH genes were in germline configuration, whereas both alleles of the T-cell receptor-beta (TCR-beta) gene were rearranged in PER-255 cells, with identical rearrangements present in the patient's leukemic cells. Cytogenetic analysis of the cell line revealed a single abnormal clone with the karyotype 46,XY,t(7;10)(q32-34;q24),t(9;12) (p22;p12-13). Reciprocal translocations involving chromosome bands 7q32-36, containing the gene for the TCR-beta chain, have been reported for a number of tumors of T-cell origin. Translocations involving the 7q32-36 region appear to be nonrandomly associated with childhood T-ALL, whereas abnormalities of 9p and 12p have been reported to be nonrandomly involved in ALL but not specifically associated with the T- cell phenotype. 相似文献
78.
Parsons DW; McAndrew PE; Monani UR; Mendell JR; Burghes AH; Prior TW 《Human molecular genetics》1996,5(11):1727-1732
The gene for autosomal recessive spinal muscular atrophy (SMA) has been
mapped to 5q12 in a region that contains repeated markers and genes. Three
cDNAs that detect deletions in SMA patients have been reported. One of
these, the survival motor neuron (SMN) cDNA, is encoded by two genes (SMNT
and SMNC) which are distinguished by base changes in exons 7 and 8. Exon 7
of the SMNT gene is not detectable in approximately 95% of SMA cases, due
either to deletion or sequence conversion. There is limited information on
the mutations in SMA patients that have detectable SMNT, these are critical
for confirmation of SMNT as the SMA gene. Using SSCP analysis of the SMN
exons we screened our SMA patients that possess at least one intact SMNT
allele for mutations in SMNT. We identified one type I SMA patient with an
11 bp duplication in exon 6 which causes a frameshift and premature
termination of the deduced SMNT protein. Dosage and SSCP analysis of SMNT
in this family indicated that the father contributed a SMNT-deleted allele
to the affected child whereas the mother passed on the 11 bp exon 6
duplication SMNT allele. Analysis of RNA by RT-PCR conclusively
demonstrated that the 11 bp duplication is associated with the SMNT locus
and not SMNC. This mutation provides strong support for SMN as the
SMA-determining gene and indicates that disruption of SMNT on its own is
sufficient to produce a severe type I SMA phenotype.
相似文献
79.
80.
非痴呆老年人认知功能的差异性:从成功老化到轻度认知损伤 总被引:5,自引:2,他引:3
目的:对非痴呆的自诉记忆力减退的老年人,就其总体认知水平而言可能存在相对同源的不同亚型进行初步探讨。方法:对34例调查者进行临床记忆量表等17种神经心理测验,将结果进行Q型聚类分析。结果:15例调查者被诊断为轻度认知损伤,占44%;聚类分析产生6类新样本。结论:在正常老化与早期阿尔茨海默病这一过渡期内,老年人的认知状态是不均质的,其中既有成功老化,也有一般老化,尤其是还存在着具有痴呆发病危险性的认知损伤。 相似文献